A disease state that may be present in any age group. Primary Immunodeficiency is often undiagnosed for long periods of time because it is hidden by a wide variety of clinical symptoms.
Primary Immunodeficiencies (PID) are mostly due to genetic disorders, a mutation in genes coding for immune system components. It is often an inherited disorder. Infants are born with the disease although it may not be apparent until adulthood. It is therefore important to consider PID as a diagnosis for patients of all ages - babies, children and adults.
Clinical Symptoms
A patient with PID may present with a variety of clinical symptoms which are treated by the clinician.
- Recurrent infections throughout life due to common or rare pathogens
- Severe infections that require intensive treatment and often hospitalisation or lead to lifelong disability or, rarely, death
- Persistent infections that result in many months away from school or work as the patient does not respond to antibiotic therapy
However the underlying cause of these infections may not be considered.
The number of PID patients per million population varies from country to country but a mean value for patients needing immediate treatment has been quoted as 25 per million (European Society for Immunodeficiencies - ESID).1
There are estimated to be at least twice as many more patients with milder forms of PID who also require treatment. ESID estimated that as many as 70-90% of PID cases worldwide are still undiagnosed, resulting in unnecessary suffering for the patients and increased dependency on healthcare resources for the treatment of lifelong complications and disabilities.
Primary Immunodeficiency (PID) Pocket Guide
Primary Immunodeficiency (PID) Pocket Guide
A pocket size guide that highlights the clinical warning signs for PID and summarises the ESID3 recommendations for a diagnostic protocol.
Request your copy using the relevant codes below:
MKG423.1 - International English version (Non-US)
MKG435.1 - Spanish language version
MKG528 - German language version
This colourful poster (841mm x 594mm, A1) shows the main immune defects and diseases that are associated with primary and acquired immunodeficiency.
The poster was originally produced by Prof. med. Harald Renz and Dr. med. Ileana Herzum, Department of Clinical Chemistry and Molecular Diagnostics of the University Hospital Gießen and Marburg GmbH, Marburg site, in association with Binding Site GmbH.
It highlights the main disorders of the immune system and summarises the routine and more specialised testing that is required to diagnose those disorders. It also shows the link between acquired immunodeficiency and conditions such as leukaemia and autoimmune diseases.
It is an ideal reference and training tool for Immunology laboratories involved in the diagnosis of immune deficiency disorders.
Request your copy using the relevant codes below:
MKG429 - English (A1)
MKG428 - French (A1)
AI035 - German DIN A1, AI036 - German DIN A3, AI037 - German DIN A4
Request your copy of the Primary Immunodeficiency brochure - MKG474 .jpg)
- European Society for Immunodeficiencies (ESID) www.esid.org
